Invasive lobular triple negative carcinoma of breast: A clinico-pathological study done in south eastern part of India

Background: Triple Negative Breast Carcinomas (TNBC) are breast carcinomas which negative for Estrogen receptor (ER) Progesterone (PR) and no overexpression of Human Epidermal Growth Factor receptor-2 (HER-2). The five-year survival rate in general is good but the same bad TNBC. TNBC has got worse prognosis compared to hormone positive carcinomas. Aim: aim present study compare invasive lobular with ductal morphologic, immunohistochemical prognostic parameters. Materials Methods: One-year was done at Tertiary Care Centre. Patients all ages were included. Most them 4th 5th decade. Mammography, FNAC Biopsy done. Formalin-fixed mastectomy specimens received MGM hospital screened, diagnosed histopathologically carcinoma over a period one year. Immunohistochemistry (IHC) performed diagnose Results: Total cases – 72. No Cases ER, PR or Her 2/neu 61. (Triple negative) 11 Percentage 15 %. TNBCs show high grade mitotic count 74% 82% respectively. Other hand, some 60% showed only ER positivity without Her-2 25% PR. Invasive subtype reported 18%. Conclusion: Overall aggressive tumors more common younger age groups. Whereas associated decade other subtypes.